COMPUTATIONAL BIOLOGY AND IMMUNO-ONCOLOGY (CBIO)

We are developing and using computational approaches for integrative analyses of multi-omics and next-generation sequencing data in order to gain a network-level view of the studied system for a variety of applications. We aim to predict and test novel drug targets, biomarkers, and biological mechanisms (e.g. immune escape) to treat cancer more effectively with a focus on cancer immunology based therapeutic solutions.

Using clinical data, immuno-genomic analyses, pharmacogenomics databases, machine learning approaches, and integrative data science strategies we aim to contribute to 1) personalized medicine and precision oncology, and 2) systems and network medicine, therapy resistance and vulnerabilities.

Specific research questions are related to:

– Connection of DNA damage and repair with the immunome in (ovarian) cancer
– Synthetic lethal interactions determine therapeutic vulnerability of cancer
– Systems analysis of microRNA-mRNA networks shaping the tumor immune environment
and other disease processes
– Prediction of tumor specific and viral antigens for therapeutic vaccination
– Soluble and tissue based predictive and prognostic biomarker
– Spatial and single cell analyses of the tumor microenvironment.

Team

Hubert Hackl
Group leader (PI)

	+43-512-9003-71403
	hubert.hackl@i-med.ac.at

Raphael Gronauer
Bioinformatics, PhD Student

	+43-512-9003-70819
	raphael.gronauer@i-med.ac.at

Pablo Monfort Lanzas
Bioinformatics, PhD Student

Institute of Medical Biochemistry, Biochemical Immunotoxicology

	+43-512-9003-70819
	pablo.monfort@i-med.ac.at

Leonie Madersbacher
Biomedical Scientist, PhD Student

	+43-512-9003-70819
	leonie.madersbacher@i-med.ac.at

Gabriel Floriani, MSc.
Computational Biologist

	+43-512-9003-71410
	gabriel.floriani@i-med.ac.at

Katja Rungger, BSc.
Master student

	+43-512-9003-71410
	katja.runger@student.uibk.ac.at

Lukas Küng, BSc.
Master student

	+43-512-9003-71410
	lukas.kueng@student.i-med.ac.at

Konstantin Wilhelmy, BSc.
Master student

	+43-512-9003-71410
	konstantin.wilhelmy@student.uibk.ac.at

Alumni

Falk Gogolla, Markus Ausserhofer, Hendrik Gottschling, Miriam Federer, Matthias Leitner, Christoph Schatz

Projects

– OeNB Anniversary fund (PI): Connection of DNA damage and repair with the immunome in high grade serous ovarian cancer
– FWF Austrian Science Fund (Co-PI): MicroRNAs as predictive biomarker for COVID-19
– Pharmaceutical & Biotech company partners: Computational cancer immunology

Publications

list of publications